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- Title
Anti-adipogenic effect of Artemisia annua in diet-induced-obesity mice model.
- Authors
Hye Kyung Baek; Hyeji Shim; Hyunmook Lim; Minju Shim; Chul-Kyu Kim; Sang-Kyu Park; Yong Seok Lee; Ki-Duk Song; Sung-Jo Kim; Sun Shin Yi
- Abstract
Obesity has increased continuously in western countries during the last several decades and recently become a problem in developing countries. Currently, anti-obesity drugs originating from natural products are being investigated for their potential to overcome adverse effects associated with chemical drugs. Artemisinic acid, which was isolated from the well-known anti-malaria herb Artemisia annua (AA) L., was recently shown to possess anti-adipogenic effects in vitro. However, the anti-adipogenic effects of AA in animal models have not yet been investigated. Therefore, we conducted daily oral administration with AA water extract in a diet-induced obesity animal model and treated 3T3-L1 cells with AA to confirm the anti-adipogenic effects in the related protein expressions. We then evaluated the physiology, adipose tissue histology and mRNA expressions of many related genes. Inhibition of adipogenesis by the AA water extract was observed in vitro. In the animal model, weight gain was significantly lower in the AA treated group, but there were no changes in food intake volume or calories. Reductions in lipid droplet size and mRNA expression associated with adipogenesis were also observed in animal epididymal fat. This study is the first to report that AA has an anti-obese effects in vivo.
- Subjects
ARTEMISIA annua; OBESITY; ANTIOBESITY agents; LABORATORY mice; DEVELOPING countries; WESTERN countries
- Publication
Journal of Veterinary Science, 2015, Vol 16, Issue 4, p389
- ISSN
1229-845X
- Publication type
Article
- DOI
10.4142/jvs.2015.16.4.389