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- Title
Determining the extent to which delayed-enhancement images reflect the partition-coefficient of Gd-DTPA in canine studies of reperfused and unreperfused myocardial infarction.
- Authors
Thornhill, Rebecca E.; Prato, Frank S.; Wisenberg, Gerald; Moran, Gerald R.; Sykes, Jane
- Abstract
MRI after a constant infusion (CI) of Gd-DTPA has been used to identify the extent of myocardial infarction (MI). However, Gd-DTPA-enhanced 'viability' imaging is more commonly performed with a bolus (for 'delayed-enhancement' (DE) imaging). This study sought to determine how image delay time and time postinfarction influence the assessment of necrosis by DE. Both infusion and DE imaging was performed in dogs with reperfused ( N = 6) or unreperfused ( N = 4) MI. Estimates of the partition-coefficient of Gd-DTPA (λ) with DE were compared with those calculated after 60 min of infusion, and the comparisons were repeated until 4 (reperfused) or 8 (unreperfused) weeks postinfarction. In reperfused animals, the concordance ( R c) between DE and infusion estimates of λ was > 0.90 for most image delays > 8 min postinjection, for day 0 through week 3, with R c at day 0 greater than at week 4 ( P = 0.022). In unreperfused animals, there was an interaction between image delay time and time postinfarction ( P < 0.001): R c > 0.90 corresponded to longer image delays at week 1 than at weeks 4-8. Therefore, when image delays are selected appropriately, DE images can strongly reflect λ and identify irreversibly injured myocardium. Magn Reson Med 52:1069-1079, 2004. © 2004 Wiley-Liss, Inc.
- Publication
Magnetic Resonance in Medicine, 2004, Vol 52, Issue 5, p1069
- ISSN
0740-3194
- Publication type
Article
- DOI
10.1002/mrm.20236