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- Title
Increased default mode network connectivity and increased regional homogeneity in migraineurs without aura.
- Authors
Zhang, Jilei; Su, Jingjing; Wang, Mengxing; Zhao, Ying; Yao, Qian; Zhang, Qiting; Lu, Haifeng; Zhang, Hui; Wang, Shuo; Li, Ge-Fei; Wu, Yi-Lan; Liu, Feng-Di; Shi, Yan-Hui; Li, Jianqi; Liu, Jian-Ren; Du, Xiaoxia
- Abstract
Background: The precuneus/posterior cingulate cortex, which has been associated with pain sensitivity, plays a pivotal role in the default mode network. However, information regarding migraine-related alterations in resting-state brain functional connectivity in the default mode network and in local regional spontaneous neuronal activity is not adequate. Methods: This study used functional magnetic resonance imaging to acquire resting-state scans in 22 migraineurs without aura and in 22 healthy matched controls. Independent component analysis, a data-driven method, was used to calculate the resting-state functional connectivity of the default mode network in the patient and healthy control groups. Regional homogeneity (ReHo) was used to analyse the local features of spontaneous resting-state brain activity in the migraineurs without aura. Results: Compared with the healthy controls, migraineurs without aura showed increased functional connectivity in the left precuneus/posterior cingulate cortex within the default mode network and significant increase in ReHo values in the bilateral precuneus/posterior cingulate cortex, left pons and trigeminal nerve entry zone. In addition, functional connectivity was decreased between the areas with abnormal ReHo (using the peaks in the precuneus/posterior cingulate cortex) and other brain areas. Conclusions: The abnormalities in the precuneus/posterior cingulate cortex suggest that migraineurs without aura may exhibit information transfer and multimodal integration dysfunction and that pain sensitivity and pian processing may also be affected.
- Subjects
CHINA; BIOLOGICAL transport; BRAIN; BRAIN mapping; CEREBRAL cortex; COGNITION; INTERVIEWING; MAGNETIC resonance imaging; RESEARCH methodology; MIGRAINE; NEURORADIOLOGY; NOCICEPTORS; PROBABILITY theory; RESEARCH funding; T-test (Statistics); PAIN measurement; VISUAL analog scale; CASE-control method; DISEASE duration; NEURAL pathways; PAIN threshold
- Publication
Journal of Headache & Pain, 2016, Vol 17, Issue 1, p1
- ISSN
1129-2369
- Publication type
Article
- DOI
10.1186/s10194-016-0692-z