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- Title
The crystal structure of Z-DNA with untypically coordinated Ca<sup>2+</sup> ions.
- Authors
Luo, Zhipu; Dauter, Zbigniew
- Abstract
DNA oligomer duplexes with alternating cytosines and guanines in their sequence tend to form helices of the Z-DNA type, where the sugar and phosphate backbone forms a left-handed helix in a zigzag fashion with a repeat of two successive Watson–Crick pairs of nucleotides. Z-DNA duplexes often crystallize in complexes with diverse metal ions interacting with polar DNA atoms in various ways. This work describes the high-resolution crystal structure of a Z-DNA d(CGCGCG)2 duplex in complex with Ca2+ ions, unusually coordinated as an approximate pentagonal bipyramid by two neighboring guanines through their O6 and N7 atoms and a water molecule in the equatorial plane and a phosphate oxygen atom and another water molecule in the apical positions.
- Subjects
CRYSTAL structure; DNA; OLIGOMERS; CALCIUM ions; CYTOSINE; GUANINE; HELICAL structure
- Publication
Journal of Biological Inorganic Chemistry (JBIC), 2018, Vol 23, Issue 2, p253
- ISSN
0949-8257
- Publication type
Article
- DOI
10.1007/s00775-017-1526-4