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- Title
EPR interpretation, magnetism and biological study of a Cu(II) dinuclear complex assisted by a schiff base precursor.
- Authors
Das, Kuheli; Patra, Chiranjit; Sen, Chandana; Datta, Amitabha; Massera, Chiara; Garribba, Eugenio; El Fallah, Mohamed; Beyene, Belete; Hung, Chen-Hsiung; Sinha, Chittaranjan; Askun, Tulin; Celikboyun, Pinar; Escudero, Daniel; Frontera, Antonio
- Abstract
A new Cu(II) dinuclear complex, CuL ( 1) was afforded employing the potentially pentatentate Schiff base precursor HL, a refluxed product of o-vanillin and diethylenetriamine in methanol. Complex 1 was systematically characterized by FTIR, UV-Vis, emission and EPR spectrometry. The single crystal X-ray diffraction analysis of 1 reveals that the copper atom exhibits a distorted square planar geometry, comprising two pairs of phenolato-O and imine-N donors from two different HL ligands. The temperature dependent magnetic interpretation agrees with the existence of weak antiferromagnetic interactions between the bridging dinuclear Cu(II) ions. A considerable body of experimental evidence has been accumulated to elucidate the magneto-structural relationship in this dinuclear Cu(II) complex by DFT computation. Both the ligand and complex 1 exhibit anti-mycobacterial activity and considerable efficacy on M. tuberculosis HRa (ATCC 25177) and M. tuberculosis HRv (ATCC 25618) strains. The practical applicability of the ligand and complex 1 has been examined in living cells (African Monkey Vero Cells). The MTT assay proves the non-toxicity of the probe up to 100 mg mL. Graphical abstract: A new homometallic dinuclear Cu(II) complex is afforded with a tetradentate Schiff base precursor. EPR interpretation and temperature dependent magnetic studies show that complex 1 has weak antiferromagnetic coupling and DFT computation is governed to explain the magneto-structural correlation.
- Subjects
COPPER ions; MAGNETISM; SCHIFF bases; METAL complexes; VANILLIN; DIETHYLENETRIAMINE; METHANOL
- Publication
Journal of Biological Inorganic Chemistry (JBIC), 2017, Vol 22, Issue 4, p481
- ISSN
0949-8257
- Publication type
Article
- DOI
10.1007/s00775-016-1428-x