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- Title
Activating NTRK2 and ALK receptor tyrosine kinase fusions extend the molecular spectrum of pleomorphic xanthoastrocytomas of early childhood: a diagnostic overlap with infant-type hemispheric glioma.
- Authors
Lucas, Calixto-Hope G.; Abdullaev, Zied; Bruggers, Carol S.; Mirchia, Kanish; Whipple, Nicholas S.; Alashari, Mouied M.; Lowichik, Amy; Cheshier, Samuel; Phillips, Joanna J.; Devine, Patrick; Solomon, David A.; Quezado, Martha; Aldape, Kenneth D.; Perry, Arie
- Abstract
These cases extend the molecular spectrum of anaplastic PXA to include tumors harboring I CDKN2A/B i homozygous deletion with accompanying RTK fusions rather than MAP kinase alterations. Patient #1, H&E sections revealed a high-grade glial neoplasm composed of pleomorphic tumor cells (a), along with areas of necrosis and an increased mitotic index (b). Patient #2, H&E sections revealed a solid glial neoplasm with frequent multinucleated cells (g) with GFAP-positivity (h), ALK-positivity (i), and lack of p16 protein expression by immunohistochemistry (j).
- Subjects
PROTEIN-tyrosine kinases; MOLECULAR spectra; GLIOMAS; CENTRAL nervous system tumors; MEMBRANE fusion; POSTERIOR cranial fossa
- Publication
Acta Neuropathologica, 2022, Vol 143, Issue 2, p283
- ISSN
0001-6322
- Publication type
Article
- DOI
10.1007/s00401-021-02396-y