We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Recurrent non-canonical histone H3 mutations in spinal cord diffuse gliomas.
- Authors
Sloan, Emily A.; Cooney, Tabitha; Oberheim Bush, Nancy Ann; Buerki, Robin; Taylor, Jennie; Clarke, Jennifer L.; Torkildson, Joseph; Kline, Cassie; Reddy, Alyssa; Mueller, Sabine; Banerjee, Anu; Butowski, Nicholas; Chang, Susan; Mummaneni, Praveen V.; Chou, Dean; Tan, Lee; Theodosopoulos, Philip; McDermott, Michael; Berger, Mitchel; Raffel, Corey
- Abstract
One I H3F3A i wild-type tumor instead harbored a p.K27I mutation in the I H3F3B i gene, which encodes the histone H3 variant H3.3 that is identical in amino acid sequence to the protein product encoded by the I H3F3A i gene. Case SC-9 harboring dual H3F3A p.K27M and p.G34W mutations demonstrated immunopositivity with antibodies against both histone H3 K27M-mutant protein and histone H3.3 G34W-mutant protein in virtually all tumor cells. Case SC-11 harboring H3F3B p.K27I mutation was immunonegative for histone H3 K27M-mutant protein but demonstrated loss of histone H3 lysine 27 trimethylation (H3K27me3) in the vast majority of tumor nuclei.
- Subjects
SPINAL cord; CENTRAL nervous system tumors; ASTROCYTOMAS; HISTONES; BRAIN stem
- Publication
Acta Neuropathologica, 2019, Vol 138, Issue 5, p877
- ISSN
0001-6322
- Publication type
Letter
- DOI
10.1007/s00401-019-02072-2