We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Prognostic Significance of Tumorigenic Cells With Mesenchymal Features in Pancreatic Adenocarcinoma.
- Authors
Rasheed, Zeshaan A.; Jie Yang; Wang, Qiuju; Kowalski, Jeanne; Freed, Irwin; Murter, Christopher; Hong, Seung-Mo; Koorstra, Jan-Bart; Rajeshkumar, N. V.; Xiaobing He; Goggins, Michael; Iacobuzio-Donahue, Christine; Berman, David M.; Laheru, Daniel; Jimeno, Antonio; Hidalgo, Manuel; Maitra, Anirban; Matsui, William
- Abstract
Background: Specific populations of highly tumorigenic cells are thought to exist in many human tumors, including pancreatic adenocarcinoma. However, the clinical significance of these tumor-initiating (ie, cancer stem) cells remains unclear. Aldehyde dehydrogenase (ALDH) activity can identify tumor-initiating cells and normal stem cells from several human tissues. We examined the prognostic significance and functional features of ALDH expression in pancreatic adenocarcinoma.
- Subjects
ONCOGENIC viruses; MESENCHYME; ADENOCARCINOMA; PANCREATIC cancer; STEM cells; ALDEHYDE dehydrogenase
- Publication
JNCI: Journal of the National Cancer Institute, 2010, Vol 102, Issue 5, p340
- ISSN
0027-8874
- Publication type
Article
- DOI
10.1093/jnci/djp535