We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Prior Dengue Virus Infection Is Associated With Increased Viral Load in Patients Infected With Dengue but Not Zika Virus.
- Authors
Santiago, Gilberto A; Sharp, Tyler M; Rosenberg, Eli; Cardona, Iris I Sosa; Alvarado, Luisa; Paz-Bailey, Gabriela; Muñoz-Jordán, Jorge L
- Abstract
To evaluate potential enhancement of Zika virus (ZIKV) infection among patients with prior dengue virus (DENV) infection, we compared loads of viral RNA among patients infected with ZIKV (n = 1070), DENV-2 (n = 312), or DENV-3 (n = 260). Compared to patients without prior DENV infection, patients with prior DENV infection had significantly higher mean loads of viral RNA if infected with DENV-2 (10.6 vs 11.6 log10 GCE/mL, respectively; t test, P <.0001) or DENV-3 (10.3 vs 10.9 log10 GCE/mL; P <.0001), but not ZIKV (4.7 vs 4.7 log10 GCE/mL; P =.959). These findings provide evidence against in vivo enhancement of ZIKV by anti-DENV antibodies.
- Subjects
PUERTO Rico; DENGUE viruses; ZIKA virus; VIRAL load; VIRUS diseases; DENGUE
- Publication
Open Forum Infectious Diseases, 2019, Vol 6, Issue 7, pN.PAG
- ISSN
2328-8957
- Publication type
Article
- DOI
10.1093/ofid/ofz320