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- Title
An Immunohistochemical Study of the Pathways of the Influence of Dopamine on Orexinergic Neurons in the Perifornical Area of the Hypothalamus.
- Authors
Morina, I. Yu.; Mikhrina, A. L.; Romanova, I. V.
- Abstract
Confocal microscopy was used to analyze double immunolabeling and provided evidence of the locations of a large number of tyrosine hydroxylase-immunopositive processes around the bodies of orexinergic neurons located in the perifornical area of the hypothalamus in rats. The bodies of orexinergic neurons were found to bear dopamine D1 receptors. A high level of colocalization of dopamine D1 and D2 receptors was found in the perifornical area, which is evidence for the formation of heterodimeric D1/D2 complexes. After i.p. administration of the selective D1 receptor antagonist SCH 39166, neurons in the perifornical area showed increases in the optical density of c-Fos protein in both orexinergic neurons and their adjacent GABA neurons. These data provide evidence that dopamine is able to influence orexinergic neurons both via a direct route involving D1- and D2-dependent signal pathways and via influences on GABA neurons.
- Subjects
DOPAMINERGIC neurons; DOPAMINE receptors; HYPOTHALAMUS; OPACITY (Optics); CONFOCAL microscopy; GABA
- Publication
Neuroscience & Behavioral Physiology, 2019, Vol 49, Issue 9, p1100
- ISSN
0097-0549
- Publication type
Article
- DOI
10.1007/s11055-019-00846-5