We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Effects of Banana, Orange, and Apple on Oxidative Stress-Induced Neurotoxicity in PC12 Cells.
- Authors
Heo, H. J.; Choi, S. J.; Choi, S.-G.; Shin, D.-H.; Lee, J. M.; Lee, C. Y.
- Abstract
Banana, orange, and apple are the major fruits in Western and Asian diets. In order to find the effects of these fruits, neuron like PC12 cells were exposed to the extracts of these fruits before H2O2 treatment. We found a significant viability of PC12 cells by the MTT reduction test, which indicated that the phenolics of banana, orange, and apple fruits prevented oxidative stress-induced neurotoxicity. Additional tests by lactate dehydrogenase and trypan blue exclusion assays showed that the extracts reduced oxidative stress-induced neuronal cell membrane damage. These results suggest that fresh apples, banana, and orange in our daily diet along with other fruits may protect neuron cells against oxidative stress-induced neurotoxicity and may play an important role in reducing the risk of neurodegenerative disorders such as Alzheimer's disease.
- Subjects
APPLES; ORANGES; BANANAS; NEUROTOXICOLOGY; OXIDATIVE stress; ALZHEIMER'S disease
- Publication
Journal of Food Science (Wiley-Blackwell), 2008, Vol 73, Issue 2, pH28
- ISSN
0022-1147
- Publication type
Article
- DOI
10.1111/j.1750-3841.2007.00632.x