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- Title
A family history of Type 2 diabetes is associated with increased plasma levels of C-reactive protein in non-smoking healthy adult women.
- Authors
Pannacciulli, N.; De Pergola, G.; Giorgino, F.; Giorgino, R.
- Abstract
Abstract Aims The aim of our study was to test whether a family history of Type 2 diabetes (FH) in women is associated with plasma C-reactive protein (CRP). Methods CRP plasma levels were measured in 162 women, aged 18–60 years; 95 had a positive family history of Type 2 diabetes in a parent or grandparent (FH+ ), and 67 gave no family history of this disease (FH - ). Other measurements included: central fat accumulation, as evaluated by waist circumference; insulin resistance, as calculated by homeostatic model assessment (HOMA IR ); systolic and diastolic blood pressure; and fasting concentrations of glucose, insulin, and lipids. Results CRP plasma levels were significantly higher in FH+ than in FH - subjects. Moreover, CRP was independently associated with age, body mass index, waist circumference, HOMA IR , and FH. Conclusions Our study, performed in a selected population of women free from well-known risk factors for atherothrombosis, demonstrates that subjects with a family history of Type 2 diabetes have higher CRP plasma levels than age- and BMI-matched controls with no family history. Our results show that a family history of Type 2 diabetes is an independent contributor of CRP concentrations, in addition to age, total fatness, central fat accumulation, and insulin resistance. Diabet. Med. 19, 689–692 (2002).
- Subjects
TYPE 2 diabetes; C-reactive protein; FAMILIAL diseases
- Publication
Diabetic Medicine, 2002, Vol 19, Issue 8, p689
- ISSN
0742-3071
- Publication type
Article
- DOI
10.1046/j.1464-5491.2002.00770.x