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- Title
Millet seed oil activates β-catenin signaling and promotes hair growth.
- Authors
Eunyoung Lee; Hyo-Deok Seo; Daedong Kim; So-Hyun Park; Soo Ro Kim; Changhun Hyun; Jeong-Hoon Hahm; Tae-Youl Ha; Jiyun Ahn; Chang Hwa Jung
- Abstract
Alopecia, regardless of gender, exacerbates psychological stress in those affected. The rising prevalence of alopecia has fueled a research interest in preventing hair loss. This study investigates the potential of millet seed oil (MSO) in promoting the proliferation of hair follicle dermal papilla cells (HFDPC) and stimulating hair growth in animals with testosterone-dependent hair growth inhibition as part of a study on dietary treatments to improve hair growth. MSO-treated HFDPC significantly increased cell proliferation and phosphorylation of AKT, S6K1, and GSK3ß proteins. This induces ß-catenin, a downstream transcription factor, to translocate to the nucleus and increase the expression of factors related to cell growth. In a C57BL/6 mice model in which hair growth was inhibited by subcutaneous testosterone injection after shaving the dorsal skin, oral administration of MSO stimulated hair growth in the subject mice by increasing the size and number of hair follicles. These results suggest that MSO is a potent agent that may help prevent or treat androgenetic alopecia by promoting hair growth.
- Subjects
HAIR growth; OILSEEDS; ORAL drug administration; MILLETS; HAIR follicles; PSYCHOLOGICAL stress; CATENINS
- Publication
Frontiers in Pharmacology, 2023, p1
- ISSN
1663-9812
- Publication type
Article
- DOI
10.3389/fphar.2023.1172084