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- Title
MOZ and MORF, two large MYSTic HATs in normal and cancer stem cells.
- Authors
Yang, X.-J.; Ullah, M.
- Abstract
Genes of the human monocytic leukemia zinc-finger protein MOZ (HUGO symbol, MYST3) and its paralog MORF (MYST4) are rearranged in chromosome translocations associated with acute myeloid leukemia and/or benign uterine leiomyomata. Both proteins have intrinsic histone acetyltransferase activity and are components of quartet complexes with noncatalytic subunits containing the bromodomain, plant homeodomain-linked (PHD) finger and proline-tryptophan-tryptophan-proline (PWWP)-containing domain, three types of structural modules characteristic of chromatin regulators. Although leukemia-derived fusion proteins such as MOZ-TIF2 promote self-renewal of leukemic stem cells, recent studies indicate that murine MOZ and MORF are important for proper development of hematopoietic and neurogenic progenitors, respectively, thereby highlighting the importance of epigenetic integrity in safeguarding stem cell identity.Oncogene (2007) 26, 5408–5419; doi:10.1038/sj.onc.1210609
- Subjects
STEM cells; EMBRYONIC stem cells; ACUTE myeloid leukemia; CHROMATIN; SMOOTH muscle tumors; GENE expression
- Publication
Oncogene, 2007, Vol 26, Issue 37, p5408
- ISSN
0950-9232
- Publication type
Article
- DOI
10.1038/sj.onc.1210609