We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
ACTH Release in Rats after Removal of the Medial Hypothalamus.
- Authors
Stark, E.; Makara, G.B.; Marton, J.; Palkovits, M.
- Abstract
ACTH release in stress, measured by changesin the plasma corticosterone level, was studied in rats 24 h after isolation of the pituitary by surgical ablation of the medial hypothalamus. Injection of E. coli endotoxin or a large dose of formaldehyde induced a significant increase in ACTH release, whereas either sham-adrenalectomy under ether anesthesia or a small dose of formaldehyde did not. Resting as well as stress-induced increases in ACTH release were depressed by dexamethasone pretreatment after the removal of medial hypothalamus. It was concluded that some of the pathways through which E. coli endotoxin and a large dose of formaldehyde release corticotrophin may bypass the medial hypothalamus; and, further, that the feedback action of dexamethasone may exert itself outside the hypothalamus. Copyright © 1974 S. Karger AG, Basel
- Publication
Neuroendocrinology, 1973, Vol 13, Issue 4/5, p224
- ISSN
0028-3835
- Publication type
Article
- DOI
10.1159/000122207