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- Title
Human sever combined immune deficiency and DNA repair.
- Authors
Schwarz, Klaus; Yunmei Ma; Pannicke, Ulrich; Lieber, Michael R.
- Abstract
Human severe combined immune deficiency (SCID) is the most serious inherited immunological deficit. Recent work has revealed defects in the predominant pathway for double-strand break repair called nonhomologous DNA end joining, or NHEJ. Progress in the biochemistry and genetics of NHEJ and of human SCID has proven to be synergistic between these two fields in a manner that covers the range from biochemical etiology to considerations about possible gene therapy for the B[sup -] SCID patients.
- Subjects
IMMUNODEFICIENCY; DNA repair
- Publication
BioEssays, 2003, Vol 25, Issue 11, p1061
- ISSN
0265-9247
- Publication type
Article
- DOI
10.1002/bies.10344