We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Synthesis of Peptidoglycan Fragments from Enterococcus faecalis with Fmoc-Strategy for Glycan Elongation.
- Authors
Wang, Ning; Hasegawa, Hiroki; Huang, Cheng ‐ yuan; Fukase, Koichi; Fujimoto, Yukari
- Abstract
Peptidoglycan (PGN) is an essential structural component of the bacterial cell wall conferring cell shape, which can be recognized by host-recognition proteins and receptors as well as bacterial surface proteins. In this work, the PGN partial structures from Enterococcus faecalis that contain a tetrasaccharide and an octasaccharide with a unique heptapeptide were synthesized via an Fmoc-strategy for elongation of the glycan chains. Namely, a 4′- O-Fmoc-protected disaccharide was utilized as the key intermediate in this efficient synthetic pathway for preparing various PGN fragments. Both the tetrasaccharide and octasaccharide with the unique heptapeptide were successfully synthesized for the first time.
- Subjects
PEPTIDOGLYCANS; ENTEROCOCCUS faecalis; GLYCANS; BACTERIAL cell walls; PEPTIDES
- Publication
Chemistry - An Asian Journal, 2017, Vol 12, Issue 1, p27
- ISSN
1861-4728
- Publication type
Article
- DOI
10.1002/asia.201601357