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- Title
TP53 Mutation and Complex Karyotype Portends a Dismal Prognosis in Patients With Mantle Cell Lymphoma.
- Authors
Obr, Aleš; Procházka, Vít; Jirkuvová, Andrea; Urbánková, Helena; Kriegova, Eva; Schneiderová, Petra; Vatolíková, Michaela; Papajík, Tomáš
- Abstract
<bold>Background: </bold>TP53 mutation (TP53mut) and a complex karyotype (CK) were shown to be predictors of poor outcome in mantle-cell lymphoma (MCL). In this study we examined the combined effect of both of these risk factors.<bold>Patients and Methods: </bold>Patients diagnosed with MCL between January 2000 and December 2014 (n = 74) were evaluated. Forty-eight of them had available material for TP53 and cytogenetic examination. We analyzed the prognostic effect of combined TP53mut and CK in the cohort of patients treated with rituximab-containing therapy.<bold>Results: </bold>Three-year (3-y) overall survival (OS) and 3-y progression-free survival (PFS) in CK patients were shorter compared with non-CK (P = .001 for OS; P = .02 for PFS). TP53mut was a predictor of shorter survival compared with TP53 wild type (OS and PFS; P < .001). The incidence of TP53mut was not significantly associated with CK (P = .240). CK and TP53mut were predictors of inferior PFS and OS independent of age and Mantle-Cell Lymphoma International Prognostic Index, with hazard ratios of 2.35 (P = .024), 4.50 (P < .001) for PFS and 4.31 (P < .001), 5.46 (P < .001) for OS analysis in the CK and TP53mut groups, respectively. The combination of TP53mut and CK status stratified the patients into 3 prognostic groups (P < .001) with the worst outcome in patients with CK and TP53mut.<bold>Conclusion: </bold>TP53 mutation and CK occurred independently and patients harboring both had a dismal prognosis. The study suggests the importance of molecular cytogenetics and examination of the TP53mut status to be performed simultaneously before treatment.
- Subjects
THERAPEUTIC use of antineoplastic agents; CHROMOSOME abnormalities; CHROMOSOMES; COMPARATIVE studies; LONGITUDINAL method; LYMPHOMAS; RESEARCH methodology; MEDICAL cooperation; GENETIC mutation; PROGNOSIS; PROTEINS; RESEARCH; SURVIVAL; EVALUATION research
- Publication
Clinical Lymphoma, Myeloma & Leukemia, 2018, Vol 18, Issue 11, p762
- ISSN
2152-2650
- Publication type
journal article
- DOI
10.1016/j.clml.2018.07.282