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- Title
METHODS FOR MONITORING MITOCHONDRIAL TOXICITY OF NUCLEOSIDE-ANALOGUE REVERSE-TRANSCRIPTASE INHIBITORS IN HIV PATIENTS DURING ANTIRETROVIRAL THERAPY.
- Authors
Tilişcan, C.; Aramă, Victoria; Mihăilescu, Raluca; Streinu-Cercel, A.; Ion, Daniela; Aramă, Ş. S.
- Abstract
Various side effects have been associated to HIV antiretroviral therapy (ART) containing nucleoside reverse transcriptase inhibitors (NRTIs) as a result of mitochondrial toxicity. Mitochondrial DNA (mtDNA) depletion has important clinical consequences: lipodystrophy, hepatic toxicity, lactic acidosis, myopathy and polyneuropathy. Several methods have been developed in recent years in order to prevent the clinical and biological side effects during NRTIs treatment. These methods aim to predict the metabolic risk using non invasive tools. The present study aims to evaluate the current laboratory methods for mitochondrial toxicity and to assess their utility for monitoring ART toxicity.
- Subjects
HIGHLY active antiretroviral therapy; HIV; NUCLEOSIDE reverse transcriptase inhibitors; MITOCHONDRIA; MITOCHONDRIAL DNA; MUSCLE diseases; LACTIC acidosis
- Publication
Therapeutics, Pharmacology & Clinical Toxicology, 2011, Vol 15, Issue 4, p289
- ISSN
1583-0012
- Publication type
Article