We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
The gyrase inhibitor albicidin consists of p-aminobenzoic acids and cyanoalanine.
- Authors
Cociancich, Stéphane; Pesic, Alexander; Petras, Daniel; Uhlmann, Stefanie; Kretz, Julian; Schubert, Vivien; Vieweg, Laura; Duplan, Sandrine; Marguerettaz, Mélanie; Noëll, Julie; Pieretti, Isabelle; Hügelland, Manuela; Kemper, Sebastian; Mainz, Andi; Rott, Philippe; Royer, Monique; Süssmuth, Roderich D
- Abstract
Albicidin is a potent DNA gyrase inhibitor produced by the sugarcane pathogenic bacterium Xanthomonas albilineans. Here we report the elucidation of the hitherto unknown structure of albicidin, revealing a unique polyaromatic oligopeptide mainly composed of p-aminobenzoic acids. In vitro studies provide further insights into the biosynthetic machinery of albicidin. These findings will enable structural investigations on the inhibition mechanism of albicidin and its assessment as a highly effective antibacterial drug.
- Subjects
DNA topoisomerase II; XANTHOMONAS albilineans; POLYCYCLIC aromatic hydrocarbons; OLIGOPEPTIDES; AMINOBENZOIC acids; ANTIBACTERIAL agents
- Publication
Nature Chemical Biology, 2015, Vol 11, Issue 3, p195
- ISSN
1552-4450
- Publication type
Article
- DOI
10.1038/nchembio.1734