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- Title
Myopia and/or longer axial length are protective against diabetic retinopathy: a meta-analysis.
- Authors
Fu, Yu; Geng, Dengfeng; Liu, Hua; Che, Huixin
- Abstract
Purpose To evaluate the current evidence of the relationship between myopia, together with its structural and refractive component, and diabetic retinopathy ( DR) risk. Methods A systematic search was performed up to April, 2015. Summary odds ratios ( ORs) and 95% confidence intervals ( CIs) were calculated employing random-effects models. Three models were used to assess the association between myopia and risk of DR: axial length ( AL) (per millimetre increase) and DR; myopia (myopia versus non-myopia) and DR; refractive error ( RE) (per D decrease) and DR. Publication bias of the literature was evaluated using Begg's funnel plots and Egger's test. Results A total of 11 studies that met the predefined criteria were included in this meta-analysis. Overall, longer AL (per millimetre increase) was associa-ted with a significantly decreased risk of DR (combined OR, 0.75; 95% CI, 0.65-0.86; p < 0.001); myopic eyes (myopia versus non-myopia) showed a lower risk of DR (combined OR, 0.70; 95% CI, 0.58-0.85; p < 0.001). A greater degree of myopic RE (per D decrease) also revealed a significantly decreased risk of DR (combined OR, 0.89; 95% CI, 0.85-0.93; p < 0.001). The sensitivity analyses and cumulative meta-analysis showed similar results. No publication bias was detected in any of the three models. Conclusions This meta-analysis suggests that both myopic refraction and longer AL are associated with a lower risk of DR. Further studies are needed to determine exact mechanisms underpinning the protective effect of myopia against DR.
- Subjects
DIABETIC retinopathy treatment; MYOPIA; REFRACTIVE errors; META-analysis; CONFIDENCE intervals
- Publication
Acta Ophthalmologica (1755375X), 2016, Vol 94, Issue 4, p346
- ISSN
1755-375X
- Publication type
Article
- DOI
10.1111/aos.12908