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- Title
Induction chemotherapy in head and neck cancer patients followed by concomitant docetaxel-based radiochemotherapy.
- Authors
MENCOBONI, M.; GRILLO-RUGGIERI, F.; SALAMI, A.; SCASSO, F.; REBELLA, L.; GRIMALDI, A.; DELLEPIANE, M.; MORATTI, G.; BRUZZONE, A.; SPIGNO, F.; GHIO, R.; FIGLIOMENI, M.
- Abstract
MENCOBONI M., GRILLO-RUGGIERI F., SALAMI A., SCASSO F., REBELLA L., GRIMALDI A., DELLEPIANE M., MORATTI G., BRUZZONE A., SPIGNO F., GHIO R. & FIGLIOMENI M. (2010) European Journal of Cancer Care Concurrent chemoradiotherapy has become the standard of care for patients with inoperable squamous cell head and neck carcinoma. More recently, induction chemotherapy has been adopted as an approach in the management of these patients. We report the results of a phase II trial associating induction chemotherapy and concomitant chemoradiotherapy in a series of patients with inoperable squamous cell head and neck cancer. Twenty-nine patients with advanced squamous cell carcinoma ineligible for surgery were enrolled. Induction chemotherapy with docetaxel 75 mg/m and cisplatin 75 mg/m every 21 days was administered for two cycles. Radiotherapy followed the induction phase. During radiotherapy, docetaxel was administered weekly at the dose of 33 mg/m. Primary end point of the study was feasibility of treatment. Six (18%) patients failed to conclude the treatment schedule. Although response rates in evaluable patients were very high (disease control rate >90%), toxicities were a matter of concern. The reported treatment schedule proved infeasible. However, some modifications in ancillary therapies aimed at exploiting its efficacy could make it practicable.
- Subjects
ITALY; CANCER treatment; METASTASIS; CANCER chemotherapy; COMBINATION drug therapy; COMBINED modality therapy; MEDICAL errors; HEALTH outcome assessment; SQUAMOUS cell carcinoma; TUMOR classification; DOCETAXEL; TREATMENT effectiveness
- Publication
European Journal of Cancer Care, 2011, Vol 20, Issue 4, p503
- ISSN
0961-5423
- Publication type
Article
- DOI
10.1111/j.1365-2354.2010.01185.x