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- Title
Positive affect predicts cerebral glucose metabolism in late middle-aged adults.
- Authors
Nicholas, Christopher R.; Hoscheidt, Siobhan M.; Clark, Lindsay R.; Racine, Annie M.; Berman, Sara E.; Koscik, Rebecca L.; Dowling, N. Maritza; Asthana, Sanjay; Christian, Bradley T.; Sager, Mark A.; Johnson, Sterling C.
- Abstract
Positive affect is associated with a number of health benefits; however, few studies have examined the relationship between positive affect and cerebral glucose metabolism, a key energy source for neuronal function and a possible index of brain health. We sought to determine if positive affect was associated with cerebral glucose metabolismin late middle-aged adults (n=133). Participants completed the positive affect subscale of the Center for Epidemiological Studies Depression Scale at two time points over a two-year period and underwent 18F-fluorodeoxyglucose-positron emission tomography scanning. After controlling for age, sex, perceived health status, depressive symptoms, anti-depressant use, family history of Alzheimer's disease, APOE e4 status and interval between visits, positive affect was associated with greater cerebral glucose metabolismacross para-/limbic, frontal, temporal and parietal regions. Our findings provide evidence that positive affect in late midlife is associated with greater brain health in regions involved in affective processing and also known to be susceptible to early neuropathological processes. The current findings may have implications for interventions aimed at increasing positive affect to attenuate early neuropathological changes in at-risk individuals.
- Subjects
AFFECT (Psychology); GLUCOSE metabolism; CEREBRAL cortex; POSITRON emission tomography; FLUORODEOXYGLUCOSE F18; ALZHEIMER'S disease
- Publication
Social Cognitive & Affective Neuroscience, 2017, Vol 12, Issue 6, p993
- ISSN
1749-5016
- Publication type
Article
- DOI
10.1093/scan/nsx027