We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
The 24-h pattern of dgcr8, drosha, and dicer expression in the rat suprachiasmatic nuclei and peripheral tissues and its modulation by angiotensin II.
- Authors
Pidíková, Paulína; Chovancová, Barbora; Mravec, Boris; Herichová, Iveta
- Abstract
Study was focused on regulatory interactions between the circadian system and the renin--angiotensin system in control of microRNA (miRNA) biosynthesis. Responsiveness of the miRNA biosynthetic pathway, selected pre-miRNAs and clock genes to angiotensin II (AngII) infusion was analysed in the suprachiasmatic nuclei (SCN), liver, kidney and heart during a 24-h cycle. per2 exerted a rhythmic expression profile in all analysed tissues. clock expression showed a rhythmic pattern in the peripheral tissues with tissue-specific response to AngII. dgcr8 expression showed a tissue-specific rhythm only in peripheral tissues, which diminished in the heart and kidney after AngII delivery. Expression of pre-miR-30c was rhythmic in all studied peripheral tissues, pre-miR-34a expression exerted significant rhythm only in the liver. AngII delivery increased expression of pre-miR-30c and pre-miR-34a in the kidney. To conclude, peripheral oscillators are more likely to exhibit rhythmic miRNA biosynthesis responsive to AngII in a tissue-specific manner compared to SCN.
- Subjects
SUPRACHIASMATIC nucleus; GENE expression; ANGIOTENSINS; ANGIOTENSIN II; MOLECULAR clock; CLOCK genes
- Publication
General Physiology & Biophysics, 2022, Vol 41, Issue 5, p417
- ISSN
0231-5882
- Publication type
Article
- DOI
10.4149/gpb_2022033