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- Title
Applying the Retro-Enantio Approach To Obtain a Peptide Capable of Overcoming the Blood-Brain Barrier.
- Authors
Prades, Roger; Oller‐Salvia, Benjamí; Schwarzmaier, Susanne M.; Selva, Javier; Moros, María; Balbi, Matilde; Grazú, Valeria; de La Fuente, Jesus M.; Egea, Gustavo; Plesnila, Nikolaus; Teixidó, Meritxell; Giralt, Ernest
- Abstract
The blood-brain barrier (BBB) is a formidable physical and enzymatic barrier that tightly controls the passage of molecules from the blood to the brain. In fact, less than 2 % of all potential neurotherapeutics are able to cross it. Here, by applying the retro-enantio approach to a peptide that targets the transferrin receptor, a full protease-resistant peptide with the capacity to act as a BBB shuttle was obtained and thus enabled the transport of a variety of cargos into the central nervous system.
- Subjects
BLOOD-brain barrier; TRANSFERRIN receptors; CENTRAL nervous system; PROTEOLYTIC enzymes; PEPTIDES
- Publication
Angewandte Chemie International Edition, 2015, Vol 54, Issue 13, p3967
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201411408