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- Title
Stereoselective Synthesis of Chiral α-Amino-β-Lactams through Palladium(II)-Catalyzed Sequential Monoarylation/Amidation of C(sp<sup>3</sup>)H Bonds.
- Authors
Zhang, Qi; Chen, Kai; Rao, Weihao; Zhang, Yuejun; Chen, Fa‐Jie; Shi, Bing‐Feng
- Abstract
Give Me an Ar, give Me an N! Arylation of the methyl group in a simple derivative of readily available alanine under palladium catalysis was followed by intramolecular amidation at the same position to give chiral α‐amino‐β‐lactams with a wide range of aryl substituents (see scheme; Phth=phthaloyl). The α‐amino‐β‐lactams were obtained in moderate to high yields with good functional‐group tolerance and high diastereoselectivity.
- Subjects
STEREOSELECTIVE reactions; PALLADIUM; LACTAMS; STERIC hindrance; STEREOCHEMISTRY
- Publication
Angewandte Chemie International Edition, 2013, Vol 52, Issue 51, p13588
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201306625