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- Title
Elimination Reactions of Esters in the Biosynthesis of Polyketides and Ribosomal Peptides.
- Authors
Krawczyk, Bartlomiej; van Herwerden, Eric F.; Overkleeft, Herman S.; Süssmuth, Roderich D.
- Abstract
Enoyl intermediates are normally obtained through β‐elimination of β‐hydroxy carbonyl compounds. The OH group is eliminated either directly or is first activated through phosphorylation. Alternative strategies have now been identified: Glutamination or acetylation of a β‐hydroxycarbonyl compound followed by β‐elimination of an ester was proven to be a key step in the biosynthesis of class I lantipeptide and tetronate antibiotics.
- Subjects
WATER research; HYDROXYCARBONYLS; CARBON; FATTY acids; BIOSYNTHESIS; CARBONYL group; POLYKETIDES
- Publication
Angewandte Chemie International Edition, 2013, Vol 52, Issue 35, p9082
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201304851