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- Title
Double lung transplantation is better than single lung transplantation for end-stage chronic obstructive pulmonary disease: a meta-analysis.
- Authors
Fang, Yu-Chi; Cheng, Wen-Hsin; Lu, Hung-I; Wang, Yi-Shi; Chuang, Kai-Hao; Lai, Hsing-Hua; Chen, Yu; Chen, Li-Chun; Tsai, Meng-Yun; Chang, Yu-Ping; Huang, Kuo-Tung; Lo, Chien-Ming
- Abstract
Background: Lung transplantation is one of the most common treatment options for patients with end-stage chronic obstructive pulmonary disease. However, the choice between single and double lung transplantation for these patients remains a matter of debate. Therefore, we performed a systematic search of medical databases for studies on single lung transplantation, double lung transplantation, and chronic obstructive pulmonary disease. Methods: The rate ratio and hazard ratio of survival were analyzed. The meta-analysis included 15 case–control and retrospective registry studies. Results: The rate ratios of the 3-year survival (0.937 and P = 0.041) and 5-year survival (0.775 and P = 0.000) were lower for single lung transplantation than for double lung transplantation. However, the hazard ratio did not differ significantly between the two. Conclusions: Double lung transplantation was found to provide better benefits than single lung transplantation in terms of the long-term survival in patients with chronic obstructive pulmonary disease.
- Subjects
CHRONIC obstructive pulmonary disease; LUNG transplantation; MEDICAL databases; OVERALL survival
- Publication
Journal of Cardiothoracic Surgery, 2024, Vol 19, Issue 1, p1
- ISSN
1749-8090
- Publication type
Article
- DOI
10.1186/s13019-024-02654-6