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- Title
Malignant histiocytoses developing in patients with B-cell lymphomas. Report of two cases.
- Authors
Baer, Maria R.; Krantz, Sanford B.; Cousar, John B.; Glick, Alan D.; Collins, Robert D.; Baer, M R; Krantz, S B; Cousar, J B; Glick, A D; Collins, R D
- Abstract
Two patients with indolent B-cell lymphomas (small B-cell and small cleaved cell) developed a coexistent malignant histiocytosis 3 and 6 years after diagnosis of their lymphomas. In both patients, malignant histiocytosis presented as new onset of fever, weight loss, and rapidly progressive bulky disease super-imposed on a previously stable clinical course without constitutional symptoms. Both patients failed to respond to combination chemotherapy. The terminal aggressive phase of indolent B-cell lymphomas usually represents transformation of the original neoplasm to a large non-cleaved or immunoblastic B-cell histology. Malignant histiocytosis has not previously been reported as a second neoplasm in patients with B-cell lymphomas.
- Publication
Cancer (0008543X), 1986, Vol 57, Issue 11, p2175
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19860601)57:11<2175::AID-CNCR2820571116>3.0.CO;2-R