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- Title
The prognostic value of tumour-infiltrating lymphocytes, programmed cell death protein-1 and programmed cell death ligand-1 in Stage I–III triple-negative breast cancer.
- Authors
Sun, Guang-Yi; Zhang, Jing; Wang, Bing-Zhi; Jing, Hao; Fang, Hui; Tang, Yu; Song, Yong-Wen; Jin, Jing; Liu, Yue-Ping; Tang, Yuan; Qi, Shu-Nan; Chen, Bo; Lu, Ning-Ning; Li, Ning; Li, Ye-Xiong; Ying, Jian-Ming; Wang, Shu-Lian
- Abstract
Background: Tumour-infiltrating lymphocytes (TILs) represent a robust biological prognostic biomarker in triple-negative breast cancer (TNBC); however, the contribution of different subsets of immune cells is unclear. We investigated the prognostic value of immune markers, including stromal TILs (sTILs), CD8+T and FOPX3+T cells, PD-1 and PD-L1 in non-metastatic TNBC. Methods: In total, 259 patients with Stage I–III TNBC were reviewed. The density of sTILs along with the presence of total (t), stromal (s), and intratumoral (i) CD8+T cells and FOPX3+T cells were evaluated by haematoxylin and eosin and immunohistochemical staining. Immunohistochemical staining of PD-1, PD-L1 was also conducted. Results: All immune markers were positively correlated with each other (P < 0.05). In the multivariate analysis, sTILs (P = 0.046), tCD8+T cells (P = 0.024), iCD8+T cells (P = 0.050) and PD-1 (P = 0.039) were identified as independent prognostic factors for disease-free survival (DFS). Further analysis showed that tCD8+T cells (P = 0.026), iCD8+T cells (P = 0.017) and PD-1 (P = 0.037) increased the prognostic value for DFS beyond that of the classic clinicopathological factors and sTILs. Conclusions: In addition to sTILs, inclusion of tCD8+T, iCD8+T cells, or PD-1 may further refine the prognostic model for non-metastatic TNBC beyond that including classical factors alone.
- Publication
British Journal of Cancer, 2023, Vol 128, Issue 11, p2044
- ISSN
0007-0920
- Publication type
Article
- DOI
10.1038/s41416-023-02218-w