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- Title
Seizures in a Pediatric Patient with a Tiagabine Overdose.
- Authors
Kazzi, Ziad N.; Jones, Chris C.; D., Pharm; Morgan, Brent W.
- Abstract
Introduction: Tiagabine (TGB) is a novel antiepileptic that decreases GABA uptake. The literature contains one report of an adult with epilepsy who ingested up to 1 gram of TGB and developed status epilepticus. We reported on a pediatric patient who ingested significantly less TGB but still developed tonic-clonic seizures. Case report: A previously healthy, 13 kg, two-year-old girl developed generalized tonic-clonic seizure activity at home approximately 1 hour after ingesting 90 mg of her grandmother's TGB (forty five 2 mg tablets). At the hospital she had two 5 minute seizures at 1.5 and 3.5 hours post ingestion. Her serum TGB levels were 530 and 130 ng/ml approximately 5 and 11 hours post-ingestion (5-70 ng/ml trough levels with most probable range for seizure control). She was discharged 27 hours post ingestion, and she was in good condition. Conclusion: An overdose of TGB, a novel anti-epileptic, can cause convulsive seizures.
- Subjects
ANTICONVULSANTS; GABA; EPILEPSY; INGESTION; CHILDREN; SEIZURES (Medicine); SPASMS
- Publication
Journal of Medical Toxicology, 2006, Vol 2, Issue 4, p160
- ISSN
1556-9039
- Publication type
Article
- DOI
10.1007/BF03161185