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- Title
Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21.
- Authors
Haiman, Christopher A.; Chen, Gary K.; Blot, William J.; Strom, Sara S.; Berndt, Sonja I.; Kittles, Rick A.; Rybicki, Benjamin A.; Isaacs, William B.; Ingles, Sue A.; Stanford, Janet L.; Diver, W. Ryan; Witte, John S.; Hsing, Ann W.; Nemesure, Barbara; Rebbeck, Timothy R.; Cooney, Kathleen A.; Jianfeng Xu; Kibel, Adam S.; Hu, Jennifer J.; John, Esther M.
- Abstract
In search of common risk alleles for prostate cancer that could contribute to high rates of the disease in men of African ancestry, we conducted a genome-wide association study, with 1,047,986 SNP markers examined in 3,425 African-Americans with prostate cancer (cases) and 3,290 African-American male controls. We followed up the most significant 17 new associations from stage 1 in 1,844 cases and 3,269 controls of African ancestry. We identified a new risk variant on chromosome 17q21 (rs7210100, odds ratio per allele = 1.51, P = 3.4 × 10−13). The frequency of the risk allele is ∼5% in men of African descent, whereas it is rare in other populations (<1%). Further studies are needed to investigate the biological contribution of this allele to prostate cancer risk. These findings emphasize the importance of conducting genome-wide association studies in diverse populations.
- Subjects
GENOMICS; PROSTATE cancer; LOCUS (Genetics); DISEASE susceptibility; DISEASES in African Americans; GENE frequency; GENETIC research
- Publication
Nature Genetics, 2011, Vol 43, Issue 6, p570
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/ng.839