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- Title
Attention/memory complaint is correlated with motor speech disorder in Parkinson's disease.
- Authors
Ying Liu; Yuchang Gui; Jincui Hu; Shanshan Liang; Sixia Mo; Yuanfang Zhou; Yujian Li; Fengkun Zhou; Jianwen Xu; Liu, Ying; Gui, Yuchang; Hu, Jincui; Liang, Shanshan; Mo, Sixia; Zhou, Yuanfang; Li, Yujian; Zhou, Fengkun; Xu, Jianwen
- Abstract
<bold>Background: </bold>The mechanisms underlying the online modulation of motor speech in Parkinson's disease (PD) have not been determined. Moreover, medical and rehabilitation interventions for PD-associated motor speech disorder (MSD) have a poor long-term prognosis.<bold>Methods: </bold>To compare risk factors in PD patients with MSD to those without MSD (non-MSD) and determine predictive independent risk factors correlated with the MSD phenotype, we enrolled 314 PD patients, including 250 with and 64 without MSD. We compared demographic, characteristic data, as well as PD-associated evaluations between the MSD group and non-MSD group.<bold>Results: </bold>Univariate analysis showed that demographic characteristics, including occupation, educational level, monthly income and speaking background; clinical characteristics, including lesions in the frontal and temporal lobes, and concurrent dysphagia; and PD-associated evaluations, including the activity of daily living (ADL) score, non-motor symptoms scale (NMSS) domain 4 score (perceptual problem), and NMSS domain 5 score (attention/memory) were all significantly different between the MSD and non-MSD group (all P < 0.05). Multivariate logistic regression analysis showed that educational level, frontal lesions, and NMSS domain 5 score (attention/memory) were independent risk factors for PD-associated MSD (all P < 0.005).<bold>Conclusions: </bold>We determined an association between MSD phenotype and cognitive impairment, reflected by low-level education and related clinical profiles. Moreover, attention and memory dysfunction may play key roles in the progression of MSD in PD patients. Further studies are required to detail the mechanism underlying abnormal speech motor modulation in PD patients. Early cognitive intervention may enhance rehabilitation management and motor speech function in patients with PD-associated MSD.
- Subjects
PARKINSON'S disease; SPEECH disorders; MOVEMENT disorders; LOGISTIC regression analysis; COGNITION disorders; NEUROPSYCHOLOGICAL rehabilitation
- Publication
BMC Neurology, 2019, Vol 19, p1
- ISSN
1471-2377
- Publication type
journal article
- DOI
10.1186/s12883-019-1535-8