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- Title
Single nucleotide polymorphisms in the Anti-Müllerian hormone (AMH IleSer) and Anti-Müllerian hormone type II receptor (AMHRII −482 A>G) as genetic markers in assisted reproduction technology.
- Authors
Karagiorga, Iro; Partsinevelos, George; Mavrogianni, Despina; Anagnostou, Elli; Zervomanolakis, Ioannis; Kallianidis, Konstantinos; Drakakis, Petros; Loutradis, Dimitris
- Abstract
Purpose: The aim of the study was to evaluate whether the presence Antimullerian hormone (AMH) and Antimullerian hormone type II receptor (AMHRII) single nucleotide polymorphisms (SNPs) IleSer and -482A>G respectively are related to the assisted reproduction outcome. Methods: A prospective cross-sectional observational study was conducted in order to assess the distribution of AMH and AMHRII SNPs in two cohorts, one of healthy women ( N = 100) and the control group and the IVF/ICSI group ( N = 151) consisted of women undergoing IVF/ICSI treatment for infertility. Furthermore, a prospective longitudinal observational study was performed on the latter group to assess possible associations of these SNPs with patients' characteristics and controlled ovarian stimulation (COS) and pregnancy outcome. Results: Among non-carriers of the AMH (IleSer) polymorphism, basal FSH levels were lower in those with more than two of previous IVF attempts and fertilization rate was statistically higher in those with peak serum E2 levels below 1500 pg/ml, whereas among non-carriers of the AMHRII (−482 A>G) polymorphism, number of follicles was higher in those with more than two previous IVF attempts and total dose of gonadotropins was lower in those with peak serum E2 levels above 1500 pg/ml. Conclusions: There was evidence that in specific subgroups of women undergoing IVF/ICSI, AMH and AMHRII SNPs may be related to patients' characteristics and controlled ovarian stimulation and pregnancy outcome and thus may provide a means for the prediction of ovarian response in specific subgroups of women entering an IVF/ICSI program.
- Subjects
ANTI-Mullerian hormone; SINGLE nucleotide polymorphisms; REPRODUCTIVE technology; GENETIC markers; LUTEINIZING hormone releasing hormone
- Publication
Journal of Assisted Reproduction & Genetics, 2015, Vol 32, Issue 3, p357
- ISSN
1058-0468
- Publication type
Article
- DOI
10.1007/s10815-014-0403-0