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- Title
The influence of a heparin-coated oxygenator during cardiopulmonary bypass on postoperative lung oxygenation capacity in pediatric patients with congenital heart anomalies.
- Authors
Watanabe, Hiroshi; Miyamura, Haruo; Hayashi, Jun-ichi; Ohzeki, Hajime; Sugawara, Masaaki; Takahashi, Yoshiki; Eguchi, Shoji; Watanabe, H; Miyamura, H; Hayashi, J; Ohzeki, H; Sugawara, M; Takahashi, Y; Eguchi, S
- Abstract
<bold>Background: </bold>Cardiopulmonary bypass (CPB) causes an inflammatory response and remarkably depresses the oxygenation capacity of the lung in pediatric patients with pulmonary hypertension. Although a heparin-coated circuit is more biocompatible than an uncoated circuit, the beneficial effect of a heparin-coated circuit on the postoperative lung function in the pediatric patients remains unknown.<bold>Methods: </bold>Sixty patients younger than 3-years-old undergoing heart operations for ventricular septal defect were divided into three groups: group I = children (n = 11) without pulmonary hypertension who underwent CPB with an uncoated oxygenator; group II = children (n = 32) with pulmonary hypertension who underwent CPB with an uncoated oxygenator; and group III = children (n = 17) with pulmonary hypertension who underwent CPB with a heparin-coated oxygenator. A respiratory index (RI) was used to assess the oxygenation capacity of the lung.<bold>Results: </bold>RI in group II was significantly higher than in group I and intubation time in group II was significantly longer than in group I. There was a positive correlation between preoperative pulmonary-systemic blood pressure ratio and RI at 3 hours post-CPB. Three and six hours post-CPB, RI in group III was significantly lower than in group II, but there was no significant difference in RI between both groups at 12 hours post-CPB.<bold>Conclusions: </bold>Pulmonary hypertensive pediatric patients were vulnerable to postperfusion lung injury. Beneficial effects of a heparin-coated oxygenator in a CPB circuit was limited to the early hours post-CPB and the postoperative clinical course was not modified by the heparin-coating of a membrane oxygenator.
- Publication
Journal of Cardiac Surgery, 1996, Vol 11, Issue 6, p396
- ISSN
0886-0440
- Publication type
journal article
- DOI
10.1111/j.1540-8191.1996.tb00070.x