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- Title
Skeletal Editing of (Hetero)Arenes Using Carbenes.
- Authors
Liu, Zhaohong; Sivaguru, Paramasivam; Ning, Yongquan; Wu, Yong; Bi, Xihe
- Abstract
(Hetero)arenes continue to prove their indispensability in pharmaceuticals, materials science, and synthetic chemistry. As such, the controllable modification of biologically significant (hetero)arenes towards diverse more‐potent complex molecular scaffolds through peripheral and skeletal editing has been considered a challenging goal in synthetic organic chemistry. Despite many excellent reviews on peripheral editing (i. e., C−H functionalization) of (hetero)arenes, their skeletal editings via single atom insertion, deletion, or transmutations have received less attention in the review literature. In this review, we systematically summarize the state‐of‐the‐art skeletal editing reactions of (hetero)arenes using carbenes, with a focus on general mechanistic considerations and their applications in natural product syntheses. The potential opportunities and inherent challenges encountered while developing these strategies are also highlighted.
- Subjects
ORGANIC synthesis; AROMATIC compounds; CARBENES; CARBENE synthesis; NATURAL products; MATERIALS science
- Publication
Chemistry - A European Journal, 2023, Vol 29, Issue 42, p1
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.202301227