We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
One-Pot Synthesis of Chiral 1-Aryl-2-Aminoethanols via Ir-Catalyzed Asymmetric Hydrogenation.
- Authors
Lei Zhang; Liming Cao; Maolin Sun; Chaoming Liang; Lei Yang; Yueyue Ma; Ruihua Cheng; Jinxing Ye
- Abstract
A straightforward synthesis approach to chiral 1-aryl-2-aminoethanols via the one-pot asymmetric hydrogenation catalyzed by Ir catalyst was developed. This tandem process involves the in situ generation of α-amino ketones via the nucleophilic substitution of α-bromoketones with amines and the Ir-catalyzed asymmetric hydrogenation of ketone intermediates to provide diverse enantiomerically enriched β-amino alcohols. The excellent yields and enantioselectivities (up to 96% yield and up to >99%ee) with a wide substrate scope in this one-pot strategy were obtained.
- Subjects
HYDROGENATION; AMINO alcohols; KETONES
- Publication
Chemistry - A European Journal, 2023, Vol 29, Issue 29, p1
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.202300367