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- Title
Photoredox/Cobalt Dual‐Catalyzed Decarboxylative Elimination of Carboxylic Acids: Development and Mechanistic Insight.
- Authors
Cartwright, Kaitie C.; Joseph, Ebbin; Comadoll, Chelsea G.; Tunge, Jon A.
- Abstract
Recently, dual‐catalytic strategies towards the decarboxylative elimination of carboxylic acids have gained attention. Our lab previously reported a photoredox/cobaloxime dual catalytic method that allows the synthesis of enamides and enecarbamates directly from N‐acyl amino acids and avoids the use of any stoichiometric reagents. Further development, detailed herein, has improved upon this transformation's utility and further experimentation has provided new insights into the reaction mechanism. These new developments and insights are anticipated to aid in the expansion of photoredox/cobalt dual‐catalytic systems.
- Subjects
COBALT; AMINO acids; INSIGHT; COBALOXIMES
- Publication
Chemistry - A European Journal, 2020, Vol 26, Issue 54, p12454
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.202001952