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- Title
Malignant phyllodes tumour of the breast mimicking endometriosis.
- Authors
Lee, Andrew H. S.; Zanetto, Ulises; Awasthi, Rachna; Hwang, Mei-Ju; Nasir, Nur Diyana Md; Ng, Cedric Chuan Young; Teh, Bin Tean; Tan, Puay Hoon
- Abstract
A 63-year-old woman presented with a clinically malignant mass. Core biopsy showed features resembling endometriosis. The glands were GATA3 and oestrogen receptor positive consistent with mammary origin and had no myoepithelial layer. The excision also showed a fibroepithelial component with stromal overgrowth, frequent mitoses and invasive margin consistent with a malignant phyllodes tumour. KMT2D and SETD2 mutations were present in both the conventional phyllodes tumour and endometriosis-like areas and are also described in endometriosis raising interesting questions about these lesions. This unusual pattern is a potential diagnostic pitfall, so it is helpful to be aware of it.
- Subjects
TUMORS; ENDOMETRIOSIS; BREAST; GLANDS; MITOSIS; ESTROGEN; BIOPSY
- Publication
Virchows Archiv: European Journal of Pathology, 2021, Vol 479, Issue 5, p1051
- ISSN
0945-6317
- Publication type
Article
- DOI
10.1007/s00428-021-03086-6