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- Title
Molecular findings in maxillofacial bone tumours and its diagnostic value.
- Authors
Cleven, Arjen H.G.; Schreuder, Willem H.; Groen, Eline; Kroon, Herman M.; Baumhoer, Daniel
- Abstract
According to the WHO, mesenchymal tumours of the maxillofacial bones are subdivided in benign and malignant maxillofacial bone and cartilage tumours, fibro-osseous and osteochondromatous lesions as well as giant cell lesions and bone cysts. The histology always needs to be evaluated considering also the clinical and radiological context which remains an important cornerstone in the classification of these lesions. Nevertheless, the diagnosis of maxillofacial bone tumours is often challenging for radiologists as well as pathologists, while an accurate diagnosis is essential for adequate clinical decision-making. The integration of new molecular markers in a multidisciplinary diagnostic approach may not only increase the diagnostic accuracy but potentially also identify new druggable targets for precision medicine. The current review provides an overview of the clinicopathological and molecular findings in maxillofacial bone tumours and discusses the diagnostic value of these genetic aberrations.
- Subjects
TUMORS; BONE cysts; INDIVIDUALIZED medicine; BONE cells; PATHOLOGISTS; FACIAL bones; GRANULOMA; FIBROUS dysplasia of bone; CHONDROSARCOMA; MAXILLARY tumors; SKULL tumors
- Publication
Virchows Archiv: European Journal of Pathology, 2020, Vol 476, Issue 1, p159
- ISSN
0945-6317
- Publication type
journal article
- DOI
10.1007/s00428-019-02726-2