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- Title
CD34<sup>+</sup> fibrocytes in chronic cystitis and noninvasive and invasive urothelial carcinomas of the urinary bladder.
- Authors
Wilhelm Nimphius; Roland Moll; Peter Olbert; Annette Ramaswamy; Peter Barth
- Abstract
Abstract??CD34+fibrocytes are constitutive elements of the connective tissue where they play a role in matrix synthesis and tumor-associated stromal remodeling. Secreted protein, acidic, and rich in cysteine (SPARC) is a pivotal mediator of stromal remodeling precipitated by invasive carcinomas. The present study was undertaken to investigate CD34+fibrocytes in the stroma of the tumor-free urinary bladder, chronic cystitis, and urothelial carcinomas together with stromal expression of ?-smooth muscle actin (?-SMA), CD117, and SPARC. In tumor-free urinary bladder and chronic cystitis, CD34+fibrocytes were found in the deep lamina propria and tunica muscularis, whereas the superficial lamina propria disclosed a CD34-negative and ?-SMA-positive fibrocyte-like cell. Invasive urothelial carcinomas revealed a complete loss of CD34+fibrocytes and concomitant appearance of ?-SMA-reactive myofibroblasts which showed strong expression of SPARC. CD117 expression of tumor-free and tumor-associated stroma revealed no differences. We in this study for the first time describe CD34+fibrocytes in the urinary bladder and an up-to-now unknown population of ?-SMA-positive fibrocytes exclusively occurring in the superficial lamina propria. Stromal remodeling associated with invasive carcinomas in the urinary bladder is characterized by a loss of CD34+fibrocytes paralleled by a gain of ?-SMA-positive myofibroblasts and increased expression of SPARC.
- Subjects
CYSTITIS; BLADDER diseases; BLADDER; URINARY organs
- Publication
Virchows Archiv: European Journal of Pathology, 2007, Vol 450, Issue 2, p179
- ISSN
0945-6317
- Publication type
Article
- DOI
10.1007/s00428-006-0347-6