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- Title
Synthesis of Functionalized Lipids, and Their Use for a Tunable Hydrophobization of Nucleosides and Nucleic Acids.
- Authors
Korneev, Sergei; Rosemeyer, Helmut
- Abstract
Two series of functionalized single and double side-chained lipid molecules ( Schemes 1 and 2) were prepared. The compounds carry either terminal COOH, OH, or halogen substituents. Moreover, the double side-chained lipid 18 carries an internal alkyne functionality. The latter compound was used to hydrophobize thymidine at N(3) by base-catalyzed alkylation. Additionally, fully protected thymidine, 32, was N(3)-alkylated with the double side-chained alcohol 9 applying Mitsunobu reaction conditions.
- Subjects
LIPIDS; CHEMICALS; HALOGENS; ALKYNES; NUCLEOSIDES; NUCLEIC acids; MITSUNOBU reaction
- Publication
Helvetica Chimica Acta, 2013, Vol 96, Issue 2, p201
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/hlca.201100410