We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
The nonspecific nature of proton spectroscopy in brain masses in children: a series of demyelinating lesions.
- Authors
Pandya, H. G.; Wilkinson, I. D.; Agarwal, S. K.; Griffiths, P. D.
- Abstract
MRI imaging has significantly improved the detection of brain lesions over the past few decades. It has high sensitivity to intracranial pathology but confident preoperative tissue diagnosis is relatively unusual. MR spectroscopy provides in-vivo biochemical information and has been used to improve the low specificity of tumour diagnosis. During the last decade there have been a number of reports making the case that proton spectroscopy can distinguish different grades of glial tumours and in some situations provide information on histological type. We report four children who presented with neurological symptoms and focal masses on MRI. MRS in each of them gave results consistent with textbook descriptions of malignancy, but in all four cases the abnormalities were subsequently shown to be due to demyelination. We reiterate that spectroscopic appearances are nonspecific and spectroscopic data should be evaluated in the light of concurrent imaging features and the clinical presentation.
- Subjects
BRAIN tumors; MAGNETIC resonance imaging; TUMORS; SPECTRUM analysis; DIAGNOSTIC imaging; DIAGNOSIS of neurological disorders; MEDICAL imaging systems
- Publication
Neuroradiology, 2005, Vol 47, Issue 12, p955
- ISSN
0028-3940
- Publication type
Article
- DOI
10.1007/s00234-003-0947-7