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- Title
Wilms Tümörü: Tek Merkezin 32 Yıllık Deneyimleri ile Güncel Literatürün Gözden Geçirilmesi.
- Authors
Özaydın, Seyithan; Karaaslan, Birgül
- Abstract
Objective: Wilms Tumor (WT) is the most common renal tumor of childhood, usually seen between the ages of 2-4 years. The survival rate is reported as 90% in non-metastatic cases and 75% in metastatic cases. In the study, it was aimed to review the current literature by presenting 32 years of WT experiences of a single center. Method: The files of 70 patients who underwent WT surgery in our Pediatric Surgery clinic between January 1988 and December 2019 were retrospectively reviewed. Results: Sixty-two of the 70 cases were unilateral and 8 were bilateral. 33 (53.2%) of unilateral cases were female, 29 (46.7%) of them were male, 5 (62.5%) of bilateral cases were female and 3 (37.5%) of them were male. The mean age was determined as 33.6 months (8-62) in unilateral cases and 25.4 months (12-54) in bilateral cases. WAGR Syndrome was found in one case. 5 of the cases were Stage I, 22 were Stage II, 19 were Stage III, 16 were Stage IV and 8 were Stage V. The most common metastasis was detected in the lung at the rate of 56% (n=9/16). While anaplasia was judged histopathologically in 12 (17.1%) of the cases, recurrence was detected in 10 (14.2%) cases. One case died peroperatively and 13 patients died during follow-up. 8 (61.5%) of those who were lost were undesirable in histopathology including anaplasia. The survival rate in our series was determined as 91% in positive cases and 33% in unfavorable cases. Conclusion: Future efforts in the treatment of WT should be to create national and international integrated data screening indexes in order to increase recovery, reduce chemotherapy toxicity and contribute to innovations in treatment, especially in high-risk cases, as in our series.
- Subjects
NEPHROBLASTOMA; PEDIATRIC surgery; METASTASIS; CANCER chemotherapy; WAGR syndrome
- Publication
Medical Journal of Istanbul Kanuni Sultan Süleyman / İstanbul Kanuni Sultan Süleyman Tıp Dergisi, 2021, Vol 13, Issue 3, p207
- ISSN
2148-273X
- Publication type
Article
- DOI
10.4274/iksstd.2021.81557