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- Title
Autoinflammatio és autoinflammatorikus kórképek.
- Authors
ZOLTÁN, SZEKANECZ; SZILVIA, SZAMOSI; SZILVIA, BENKÔ; GABRIELLA, SZŰCS
- Abstract
Autoinflammation has been linked to disorders of innate immunity. It can be monogenic or acquired. Monogenic autoinflammatory pathologies include inflammasomopathies, actinopathies, genetic abnormalities causing endoplasmic reticulum stress (protein misfolding), relopathies (NF-κB-associated diseases), type I interferonopathies, mutations in the genes of endogenous antagonists and other pathologies (e. g. DADA2). Many chronic inflammatory diseases are associated with acquired autoinflammation. These include, among others, inflammatory rheumatological diseases (e.g. gout, CPPD arthropathy, Behçet's disease, rheumatoid arthritis, spondyloarthritides, systemic juvenile idiopathic arthritis, adult onset Still's disease, osteoarthritis), Crohn’s disease, some inflammatory skin diseases (e.g. pustular psoriasis, pyoderma gangrenosum, PAPA, SAPHO, Sweet and Schnitzler syndromes), certain bone diseases (e.g. CRMO, SAPHO, inflammatory osteoporosis) and other pathologies (e.g. VEXAS, IgG4-related disease, PFAPA, recurrent pericarditis, type 2 diabetes, interstitial lung disease, atherosclerosis, Covid-19). In this review, we discuss the basic mechanisms of autoinflammation, the main autoinflammatory syndromes, the role of immunodeficiency (inborn errors of immunity) in autoinflammation, as well as current and future therapeutic attempts.
- Publication
Immunology Quaterly / Immunologiai Szemle, 2024, Vol 16, Issue 2, p7
- ISSN
2061-0203
- Publication type
Article