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- Title
Antimicrobial strategy for targeted elimination of different microbes, including bacterial, fungal and viral pathogens.
- Authors
Mitsunaga, Makoto; Ito, Kimihiro; Nishimura, Takashi; Miyata, Hironori; Miyakawa, Kei; Morita, Takeshi; Ryo, Akihide; Kobayashi, Hisataka; Mizunoe, Yoshimitsu; Iwase, Tadayuki
- Abstract
The continuous emergence of microbial pathogens for which there are no effective antimicrobials threatens global health, necessitating novel antimicrobial approaches. Here, we present a targeted antimicrobial strategy that can be applied to various microbial pathogens. A photoimmuno-conjugate composed of an antibody against the target pathogen and a photoplastic phthalocyanine-derivative probe that generates photo-induced mechanical stress was developed based on photoimmuno-technology. This strategy, named as photoimmuno-antimicrobial strategy (PIAS), eliminates targeted pathogens, regardless of the target species or drug-resistance status. Specifically, PIAS acts on a broad range of microbes, including the bacterial pathogen Staphylococcus aureus, fungal pathogen Candida albicans, including their drug-resistant strains, and viral pathogen SARS-CoV-2, the causative agent of COVID-19. Furthermore, PIAS protects mice from fatal infections without damaging the non-targeted host microbiota and tissues. This study may contribute to the development of next-generation anti-infective therapies. The PIAS system, consisting of light-sensitive dye conjugated with monoclonal antibodies, is capable of eliminating fungal, viral, and bacterial pathogens, regardless of their drug resistance status.
- Subjects
STRAINS &; stresses (Mechanics); CANDIDA albicans; PATHOGENIC microorganisms; MONOCLONAL antibodies; MICROORGANISMS; STAPHYLOCOCCUS aureus
- Publication
Communications Biology, 2022, Vol 5, Issue 1, p1
- ISSN
2399-3642
- Publication type
Article
- DOI
10.1038/s42003-022-03586-4