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- Title
Role of Lipocalin-2 in Amyloid-Beta Oligomer-Induced Mouse Model of Alzheimer's Disease.
- Authors
Kang, Heeyoung; Shin, Hyun Joo; An, Hyeong Seok; Jin, Zhen; Lee, Jong Youl; Lee, Jaewoong; Kim, Kyung Eun; Jeong, Eun Ae; Choi, Kyu Yeong; McLean, Catriona; Lee, Kun Ho; Kim, Soo Kyoung; Lee, Hae Ryong; Roh, Gu Seob
- Abstract
Lipocalin-2 (LCN2) is an inflammatory protein with diverse functions in the brain. Although many studies have investigated the mechanism of LCN2 in brain injuries, the effect of LCN2 on amyloid-toxicity-related memory deficits in a mouse model of Alzheimer's disease (AD) has been less studied. We investigated the role of LCN2 in human AD patients using a mouse model of AD. We created an AD mouse model by injecting amyloid-beta oligomer (AβO) into the hippocampus. In this model, animals exhibited impaired learning and memory. We found LCN2 upregulation in the human brain frontal lobe, as well as a positive correlation between white matter ischemic changes and serum LCN2. We also found increased astrocytic LCN2, microglia activation, iron accumulation, and blood–brain barrier disruption in AβO-treated hippocampi. These findings suggest that LCN2 is involved in a variety of amyloid toxicity mechanisms, especially neuroinflammation and oxidative stress.
- Subjects
LABORATORY mice; LIPOCALINS; ALZHEIMER'S disease; LIPOCALIN-2; ANIMAL disease models; FRONTAL lobe; AMYLOID beta-protein; OLIGOMERS
- Publication
Antioxidants, 2021, Vol 10, Issue 11, p1657
- ISSN
2076-3921
- Publication type
Article
- DOI
10.3390/antiox10111657