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- Title
Antioxidant Therapeutics in Parkinson's Disease: Current Challenges and Opportunities.
- Authors
Duarte-Jurado, Ana Patricia; Gopar-Cuevas, Yareth; Saucedo-Cardenas, Odila; Loera-Arias, Maria de Jesus; Montes-de-Oca-Luna, Roberto; Garcia-Garcia, Aracely; Rodriguez-Rocha, Humberto; Nuzzo, Domenico
- Abstract
Oxidative stress is considered one of the pathological mechanisms that cause Parkinson's disease (PD), which has led to the investigation of several antioxidants molecules as a potential therapeutic treatment against the disease. Although preclinical studies have demonstrated the efficacy of these compounds to maintain neuronal survival and activity in PD models, these results have not been reflected in clinical trials, antioxidants have not been able to act as disease modifiers in terms of clinical symptoms. Translational medicine currently faces the challenge of redesigning clinical trials to standardize criteria when testing molecules to reduce responses' variability. Herein, we discuss current challenges and opportunities regarding several non-enzymatic antioxidants' therapeutic molecules for PD patients' potential treatment.
- Subjects
PARKINSON'S disease; TRANSLATIONAL research; ANTIOXIDANTS; OXIDATIVE stress; THERAPEUTICS; CATECHOL-O-methyltransferase; CLINICAL trials
- Publication
Antioxidants, 2021, Vol 10, Issue 3, p453
- ISSN
2076-3921
- Publication type
Article
- DOI
10.3390/antiox10030453