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- Title
Response to de Nonneville, Finetti, Mamessier, and Bertucci.
- Authors
Villodre, Emilly S; Hu, Xiaoding; Huo, Lei; Debeb, Bisrat G
- Abstract
We appreciate the insightful correspondence from de Nonneville and colleagues ([1]) regarding our article "NDRG1 in Aggressive Breast Cancer Progression and Brain Metastasis." Analysis of the independent cohort also demonstrated that NDRG1 is associated with features of aggressive breast cancer such as enrichment of tumor stemness, tumor invasion and metastasis signatures, further corroborating our preclinical observations. Importantly, de Nonneville et al. ([1]) expanded their analysis to include breast tumor subtypes considered less aggressive, such as estrogen receptor (ER)+/HER2- tumors; they found that NDRG1 also positively correlates with aggressiveness and poor survival outcome in patients with these tumors.
- Publication
JNCI: Journal of the National Cancer Institute, 2022, Vol 114, Issue 7, p1048
- ISSN
0027-8874
- Publication type
journal article
- DOI
10.1093/jnci/djac032