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- Title
Assignment of Absolute Configuration to Enantiomers of Anti-Alzheimer Drug Candidate Blarcamesine.
- Authors
Szokol, Zsuzsanna; Lozsi, Károly; Virág, Attila; Dancsó, András; Szlávik, László; Simig, Gyula; Volk, Balázs
- Abstract
Blarcamesine is a promising investigational drug for the treatment of Alzheimer's disease. The international nonproprietary name blarcamesine refers to a racemic compound, although it seems likely that it will be marketed in an enantiopure form. A resolution process has been described in the literature, but the absolute configurations of the enantiomers have not yet been disclosed. In the present study, crystals of (R)-(-)- and (S)-(+)-mandelate salts of (+)- and (-)-blarcamesine and also that of (R)-(+)-blarcamesine itself, suitable for single-crystal X-ray diffraction measurement were prepared and the absolute configurations of (+)- and (-)-blarcamesine have been determined.
- Subjects
RACEMIC mixtures; ENANTIOMERS; X-ray diffraction measurement; ALZHEIMER'S disease; INVESTIGATIONAL drugs
- Publication
Periodica Polytechnica: Chemical Engineering, 2022, Vol 66, Issue 4, p536
- ISSN
0324-5853
- Publication type
Article
- DOI
10.3311/PPch.20662